Books
“The Century of the Gene” by Evelyn Fox Keller
A new book argues that there may be no such thing as a gene.
Only a few years ago, the popular media was reporting that scientists had found the gene for homosexuality, for aggression, for breast cancer. Buried in the middle of an article, perhaps, were questions about how a gene could determine complex social behavior like homosexuality, or what it could mean to say there’s a gene for a lethal disease. Still, the pervasive view has been that we are our genes; one writer predicted that one could eventually pull from one’s pocket a CD inscribed with one’s genetic sequence and say, “It’s me!”
Yet if you look carefully at recent articles in science magazines, you notice a different kind of language: Science News, for example, has reported genetic discoveries such as “Gene Tied to Prostate Cancer,” “Sinus Infections Linked to Gene” and “Gene Implicated in Diabetes.” Some very diffident verbs are carrying a lot of weight here. What precisely do “tied,” “linked” and “implicated” mean? If you read further, you discover that of the small percentage of sufferers of prostate cancer with a family history of the disease, some carry the same mutated stretch of DNA. Another chunk of mutated DNA is more common in, but not exclusive to, sinus sufferers. Not for nothing did the writers avoid saying anyone had “found the gene” for prostate cancer or sinus infections. Just what the scientists had found was still unclear.
I might not have noticed this if it were not for Evelyn Fox Keller’s latest book, “The Century of the Gene,” which traces the history of genetics. Her title implies that the era of the gene is over, and though she never puts it as baldly as that, her slim volume has a radical premise: There may be no such thing as a gene. At least, it has proved very difficult to isolate a discrete physical item that can do the work our notion of the gene does. Though the book gets quite technical, you don’t have to have a background in molecular genetics to read it. Any reader willing to think through difficult ideas explained in crystal-clear prose is in for a treat: Keller, a historian of science at MIT, elegantly demolishes one of our culture’s central dogmas.
From the moment Charles Darwin proposed his theory of evolution by natural selection, it was clear that the theory required a mechanism for the maintenance of traits through the generations. By the 20th century, when the term “gene” was coined, scientists were searching for a fundamental unit of life that would account for the capacity of life to maintain and replicate itself. When James Watson and Francis Crick identified DNA’s double-helix structure as the bearer of genetic information, they had at one elegant swoop, it seemed, found a unit that was by its very structure self-replicating. As I was taught in high school, one gene equals a stretch of DNA that makes one protein — DNA makes RNA makes protein makes us.
But, Keller explains, DNA can’t copy itself on its own. It requires cooperating enzymes. Some enable transcription, others check the accuracy of transcription and some repair miscopied DNA. Worse, scientists discovered that the stretches of DNA that are transcribed into proteins are interrupted by vast areas of apparent “junk” DNA — as much as 97 percent of the human genome — which the enzyme machinery must edit out. Scientists then learned that in editing, the enzyme apparatus “chooses” what to cut, so one chunk of DNA can lead to various proteins and, perhaps, Keller writes, as many as hundreds per “gene.” Also, some proteins can arise from several different, redundant genes. What sequence now counts as the gene?
Then there’s the obvious problem that within an organism every cell contains the same genes, yet cells differentiate into very different tissues. Some further mechanism in each cell must tell each gene whether to turn on or off and when. Here Keller, whose previous books include “Reflections on Gender and Science,” offers one of the gems that make one grateful for feminist historians of science: Assuming that the cytoplasm of a cell is purely passive, scientists drew the absurdly Aristotelian conclusion that sperm, pure nucleus, provides the activating force to the passive, cytoplasm-heavy egg cell.
Keller uses an analysis of the cloning of Dolly the sheep to explain the flaws in this theory. If the genome (residing within the nucleus) holds the developmental program, why shouldn’t it be possible to clone a new organism from the nucleus of an adult cell, rather than by transferring the nucleus of an adult cell into an enucleated egg cell, as was done in Dolly’s case? Ian Wilmut’s success in cloning Dolly depended on a not-yet-understood relationship between the nucleus and the cytoplasm of the cell. Keller argues that the genetic program that tells a cell what proteins to make exists only in the complex regulatory dynamics of the cell as a whole, and the genetic program that makes each person “consists of, and lives in, the interactive complex made up of genomic structures and the vast network of cellular machinery in which those structures are embedded. It may even be that this program is irreducible — in the sense, that is, that nothing less complex than the organism itself is able to do the job.”
By the time one finishes reading “The Century of the Gene” and learns that “the gene is not a physical object,” it is hard to recall the triumphant genetic determinism that so recently seemed all-pervasive.
As delightful as Keller’s analysis is, one wishes in the end that she had been less agnostic about the reality of genes. She sticks carefully to her focus on “gene talk” and its scientific usefulness, pointing out that it is the very success of genetics that has undermined its core concepts. Nor does she explain the wide appeal of genetic determinism. One wishes that her book had been longer. But this is praise reserved only for the best writers.
Keller has offered a decisive counterexample to the simple view that science deals only with physical objects. Yet science does seek the truth about physical reality, and if Keller is right, gene talk doesn’t describe the real world adequately. Let’s hope that the news reaches Time and Newsweek soon.
Carolyn McConnell is a writer who lives in Seattle. More Carolyn McConnell.
“People Who Eat Darkness”: The disappearing blonde
A true crime story set in Tokyo illuminates the complicated truths behind media cliches
Joji Obara and Lucie Blackman (Credit: Estate of Lucie Jane Blackman) Lucie Blackman, 21, went out for the afternoon in 2000, phoning her roommate and best friend Louise to arrange a meeting later that night. Lucie never showed up, and within a few days she’d become one of those vanished blondes whose fates fuel headlines and hours of speculative media coverage. She was British, a former flight attendant, and she and Louise were living in Tokyo. They were also bar hostesses, a profession with a very specific meaning in Japan, difficult to explain to foreigners and not entirely clear to the Japanese themselves. Lucie both did and didn’t match the classic Missing Blonde profile, and for a while the mystery of what happened to her threatened to lapse into permanent obscurity.
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Laura Miller is a senior writer for Salon. She is the author of "The Magician's Book: A Skeptic's Adventures in Narnia" and has a Web site, magiciansbook.com. More Laura Miller.
Corporate criminals gone wild
The maker of the documentary film "Inside Job" has a new book excoriating Wall Street -- and President Obama
A detail from the cover of "Predator Nation" “Inside Job,” Charles Ferguson’s Oscar-winning documentary film on how government, Wall Street and academia colluded to deliver us the worst financial crisis since the Great Depression, made a powerful case that something was very very rotten at the heart of the American political/economic nexus. His follow-up book, “Predator Nation: Corporate Criminals, Political Corruption, and the Hijacking of America,” can be considered the legal brief that dots every “i” and crosses every “t” in his argument. A tightly argued, profusely footnoted and deeply enraged castigation of everyone involved, “Predator Nation” isn’t just a factually unchallengeable account of how Wall Street blew up the global economy. It’s a denunciation, a call for justice and a warning: After getting away with the crime of the century, Wall Street still isn’t satisfied.
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Andrew Leonard is a staff writer at Salon. On Twitter, @koxinga21. More Andrew Leonard.
Can you identify?
Science shows that the only way around some readers' prejudices is to trick them
(Credit: Shutterstock/Salon) The news of recent research documenting how readers identify with the main characters in stories has mostly been taken as confirmation of the value of literary role models. Lisa Libby, an assistant professor at Ohio State University and co-author of a study published in the Journal of Personality and Social Psychology, explained that subjects who read a short story in which the protagonist overcomes obstacles in order to vote were more likely to vote themselves several days later.
The suggestibility of readers isn’t news. Johann Wolfgang von Goethe’s novel of a sensitive young man destroyed by unrequited love, “The Sorrows of Young Werther,” inspired a rash of suicides by would-be Werthers in the late 1700s. Jack Kerouac has launched a thousand road trips. Still, this is part of science’s job: Running empirical tests on common knowledge — if for no other reason than because common knowledge (and common sense) is often wrong.
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Laura Miller is a senior writer for Salon. She is the author of "The Magician's Book: A Skeptic's Adventures in Narnia" and has a Web site, magiciansbook.com. More Laura Miller.
“The Aleppo Codex”: The bizarre history of a precious book
A reporter traces the shadowy fate of the definitive version of the Hebrew Bible
Matti Friedman An ancient and priceless book, a murky history of evasions and coverups, an underground of sinister and possibly violent dealers, a former spy who drops tantalizing hints and a wily 84-year-old millionaire who says stuff like, “The problem with this story is that it could damage your health”: Are these the ingredients for a cheesy, improbable historical thriller? Yet “The Aleppo Codex,” Matti Friedman’s account of his attempts to learn the history of one of the world’s most precious books, sports all of these assets, and it’s nonfiction. If reporting this story damaged Friedman’s health, it probably happened when he realized what he’d stumbled into and his reporter’s heart started beating in doubletime.
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Laura Miller is a senior writer for Salon. She is the author of "The Magician's Book: A Skeptic's Adventures in Narnia" and has a Web site, magiciansbook.com. More Laura Miller.
Augusten Burroughs: Conquer trauma by letting it go
Salon exclusive: The best-selling memoirist says past horrors haunt us because we think about them too much. Stop
Augusten Burroughs Many people continue to feel influenced and even controlled by the things that happened to them a long time ago. Sometimes, people harbor dark, traumatic memories from childhood. Or fragments of memories — incomplete scenes, uncomfortable feelings, perhaps even a sense of certainty that something specific and terrible happened to them, but little more than this.
Others experienced something traumatic in adulthood that continues to affect them day to day many years later. Maybe an assault has left a person afraid to leave their home or enter a particular neighborhood.
Continue Reading CloseAugusten Burroughs' many books include "Runnning With Scissors," "Dry," "Sellevision," "Magical Thinking" and "Possible Side Effects." His latest book is "This Is How." More Augusten Burroughs.
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