“She was inside the vehicle and was coming out from the gate after addressing the rally when some of the youths started chanting slogans in her favor. Then I saw a smiling Bhutto emerging from the vehicle’s roof and responding to their slogans,” he said.

“Then I saw a thin, young man jumping toward her vehicle from the back and opening fire. Moments later, I saw her speeding vehicle going away,” he added.

Mangled bodies lay in a pool of blood and pieces of clothing and shoes were scattered on the road. The clothing of some victims was shredded and people covered their bodies with party flags.

There was an acrid smell of explosive fumes in the air.

Police cordoned off the street and rescuers rushed to put victims in ambulances as onlookers wailed nearby.

Bhutto was rushed to the hospital and taken into emergency surgery. She died about an hour after the attack.

Hours later, her body was carried out of the hospital in a plain wooden coffin by a crowd of supporters. Her body was expected to be transferred to an air base and brought to her hometown of Larkana.

A doctor on the team that treated her said she had a bullet in the back of the neck that damaged her spinal cord before exiting from the side of her head. Another bullet pierced the back of her shoulder and came out through her chest.

She was given open heart massage, but the main cause of death was damage to her spinal cord, he said on condition of anonymity because he was not authorized to speak to the media.

“At 6:16 p.m., she expired,” said Wasif Ali Khan, a member of Bhutto’s party who was at Rawalpindi General Hospital.

“The surgeons confirmed that she has been martyred,” Bhutto’s lawyer Babar Awan said.

Bhutto’s supporters at the hospital exploded in anger, smashing the glass door at the main entrance of the emergency unit. Others burst into tears. One man with a flag of Bhutto’s Pakistan People’s Party tied around his head was beating his chest.

“I saw her with my own eyes sitting in a vehicle after addressing the rally. Then, I heard an explosion,” Tahir Mahmood, 55, said sobbing. “I am in shock. I cannot believe that she is dead.”

Many chanted slogans against Musharraf, accusing him of complicity in her killing.

“We repeatedly informed the government to provide her proper security and appropriate equipment including jammers, but they paid no heed to our requests,” said Malik, the security adviser.

As news of her death spread, angry supporters took to the streets.

In Karachi, shop owners quickly closed their businesses as protesters set tires on fire on the roads, torched several vehicles and burned a gas station, said Fayyaz Leghri, a local police official. Gunmen shot and wounded two police officers, he said.

One man was killed in a shootout between police and protesters in Tando Allahyar, a town 120 miles north of Karachi, said Mayor Kanwar Naveed. In the town of Tando Jam, protesters forced passengers to get out of a train and then set it on fire.

Two people were killed in the southern Sindh province and two others in Lahore, police said.

Violence also broke out in Lahore, Multan, Peshawar and many other parts of Pakistan, where Bhutto’s supporters burned banks, state-run grocery stores and private shops. Some set fire to election offices for the ruling party, according to Pakistani media.

Akhtar Zamin, home minister for the southern Sindh province, said authorities would deploy troops to stop violence if needed.

Musharraf urged calm.

“I want to appeal to the nation to remain peaceful and exercise restraint,” he said.

Sharif arrived at the hospital and sat silently next to Bhutto’s body.

“Benazir Bhutto was also my sister, and I will be with you to take the revenge for her death,” he said. “Don’t feel alone. I am with you. We will take the revenge on the rulers.”

He rebutted suggestions that he could gain political capital from her demise, announcing his Muslim League-N party would boycott the elections and demanding that Musharraf resign.

“The holding of fair and free elections is not possible in the presence of Pervez Musharraf,” he said. “Musharraf is the cause of all the problems. The federation of Pakistan cannot remain intact in the presence of President Musharraf,” he told a news conference. “After the killing of Benazir Bhutto, I announce that the Pakistan Muslim League-N will boycott the elections,” Sharif said. “I demand that Musharraf should quit immediately.”

Hours earlier, four people were killed at a rally for Sharif when his supporters clashed with backers of Musharraf near Rawalpindi.

Bhutto’s death will leave a void at the top of her party, the largest political group in the country, as it heads into the elections.

Pakistan is considered a vital U.S. ally in the fight against al-Qaida and other Islamic extremists including the Taliban. Osama bin Laden and his inner circle are believed to be hiding in lawless northwest Pakistan along the border with Afghanistan.

The U.S. has invested significant diplomatic capital in promoting reconciliation between Musharraf and the opposition, particularly Bhutto, who was seen as having a wide base of support in Pakistan. Her party had been widely expected to do well in next month’s elections.

Had the PPP either won a majority of seats or enough to put together a majority coalition, Bhutto could have recaptured the job of prime minister.

Bush, speaking briefly to reporters at his ranch in Crawford, Texas, demanded that those responsible for the killing be brought to justice.

“The United States strongly condemns this cowardly act by murderous extremists who are trying to undermine Pakistan’s democracy,” said Bush, who looked tense and took no questions.

The assassination and concerns of further international instability were cited as one reason for a fall in U.S. stock prices and a rise in oil prices Thursday. In afternoon trade, the Dow Jones Industrial Average of blue chip stocks was down more than 140 points or more than 1 percent.

The U.N. Security Council also condemned the assassination.

Pakistan was just emerging from another crisis after Musharraf declared a state of emergency on Nov. 3, and used sweeping powers to round up thousands of his opponents and fire Supreme Court justices. He ended emergency rule Dec. 15 and subsequently relinquished his role as army chief, a key opposition demand. Bhutto had been an outspoken critic of Musharraf’s imposition of emergency rule.

Educated at Harvard and Oxford universities, Bhutto served twice as Pakistan’s prime minister between 1988 and 1996.

Her father was Zulfikar Ali Bhutto, scion of a wealthy landowning family in southern Pakistan and founder of the populist Pakistan People’s Party. The elder Bhutto was president and then prime minister of Pakistan before his ouster in a 1977 military coup. Two years later, he was executed by the government of Gen. Zia-ul Haq after being convicted of engineering the murder of a political opponent.

Bhutto had returned to Pakistan from an eight-year exile on Oct. 18. On the same day, she narrowly escaped injury when her homecoming parade in Karachi was targeted in a suicide attack that killed more than 140 people.

Islamic militants linked to al-Qaida and the Taliban hated Bhutto for her close ties to the Americans and support for the war on terrorism. A local Taliban leader reportedly threatened to greet Bhutto’s return to the country with suicide bombings.

Hundreds of riot police had manned security checkpoints around the rally venue Thursday, Bhutto’s first public meeting in Rawalpindi since she came back to the country.

In recent weeks, suicide bombers have repeatedly targeted security forces in Rawalpindi.

In November, Bhutto had also planned a rally in the city, but Musharraf forced her to cancel it, citing security fears.