Malaria vaccine shows promise in trial

The vaccine reduced the disease by "almost half" in five to seven month old babies

Topics: Malaria, Disease, Health, Health Care, vaccine, ,

Malaria vaccine shows promise in trial

A successful drug trial may have brought an anti–malaria treatment one step closer. GlaxoSmithKline has tested the RTS,S vaccine, which reduced the disease by almost half in five– to seven–month babies, and by a quarter in six– to 12–week olds, in clinical trials in South Africa and is now seeking a regulatory license for its use in the continent under a special provision of the European Medicines Agency.

Although the efficacy of the vaccine deteriorated slightly over time, the treatment would make a significant dent in the number of lives that are claimed by the disease in the worst–hit parts of Africa. According to the World Health Organisation, 2010 saw 219 million cases of malaria, with 660,000 of these being fatal. Almost two thirds of cases, says the agency, occur in children under 15 years of age.

The treatment, which was developed with help from U.S. not–for–profit PATH Malaria Vaccine Initiative, whose VP of product development, David Kaslow, pointed out that, for every 1,000 children vaccinated, 941 cases of malaria were averted. If it goes ahead, GSK will make the vaccine a not–for–profit treatment, but will add an extra 5% to the cost price in order to fund more R&D on tropical diseases. Forty people alone are needed to analyse the paperwork––one million pages of it––from the trials.



Efforts to stop malaria in its tracks are varied––from low–tech campaigns, such as fines for villagers who do not use mosquito nets to campaigns to drum up money and support. But perhaps the disease’s most high–profile avengers are Bill and Melinda Gates, whose eponymous foundation has invested $200 million in the research on RTS,S. The couple have been behind all sorts of innovations, from hand–held lasers that zap the mosquitos––called the WMD, or Weapon of Mosquito Destruction––to smartphone apps.

Featured Slide Shows

  • Share on Twitter
  • Share on Facebook
  • 1 of 11
  • Close
  • Fullscreen
  • Thumbnails

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Elliott and the friends with whom he recorded in middle school in Texas (photo courtesy of Dan Pickering)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Heatmiser publicity shot (L-R: Tony Lash, Brandt Peterson, Neil Gust, Elliott Smith) (photo courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Elliott and JJ Gonson (photo courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    "Stray" 7-inch, Cavity Search Records (photo courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Elliott's Hampshire College ID photo, 1987

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Elliott with "Le Domino," the guitar he used on "Roman Candle" (courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Full "Roman Candle" record cover (courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Elliott goofing off in Portland (courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    Heatmiser (L-R: Elliott Smith, Neil Gust, Tony Lash, Brandt Peterson)(courtesy of JJ Gonson photography)

    "Roman Candle" turns 20: Secrets of Elliott Smith's accidental masterpiece (slideshow)

    The Greenhouse Sleeve -- Cassette sleeve from Murder of Crows release, 1988, with first appearance of Condor Avenue (photo courtesy of Glynnis Fawkes)

  • Recent Slide Shows

Comments

Loading Comments...