Playboy’s long-running interview column is often a place where subjects feel free to run their mouths a little — right, Gary Oldman? — and as you’d expect, Bill Maher does not hold back. In the latest issue’s interview, conducted by contributing editor David Hochman, the polemical “Real Time” host sounds off on all sorts of contentious issues, from sex and vaccines to Obama and radical Islam. Here are eight of the juiciest quotes, or you can read the full interview over at Playboy.

On vaccines:

“I’ve never argued that vaccines don’t work. I just don’t think you need them. There are so many maladies now that used to be rare and now are much more prevalent—things like allergies, ADD, asthma, migraines, autoimmune disorders, chronic fatigue, colitis, more colds. I’m not saying vaccines cause any of them, but the modern immune system might be less robust than it used to be because it doesn’t get its full workout going through a disease like the measles. I’m glad vaccines exist, just like I’m glad antibiotics exist, but we’ve abused the hell out of them. Bugs that no antibiotic works on anymore? I worry about that a lot more.”

On Americans’ puritanical attitudes to sex:

“We pride ourselves on being a modern country, but we are big f**king babies when it comes to sex. Puritanism is one of those dominoes that have to fall, along with pot and gay marriage. The way the media and the population respond to these so-called sex scandals, I mean, Jesus! Celebrity sex videos, sexting scandals, Eliot Spitzer, Bill Clinton, slut-shaming from the left and the right. People! Eliot Spitzer made a mistake, a private mistake, and we’ve exiled him. He’s a brilliant guy who is now toxic? This is horsesh*t. More than any other Democrat, he went after Wall Street, which is much more important than this nonsense about who he’s f**king. He can’t have a place in public life anymore because he was with a prostitute? This is what I mean about stupidity. Sex has nothing to do with job performance. It’s nobody’s business.”

On pornography nowadays:

“Today, the stuff kids have access to is fucking unbelievable. The idea that you can sit in the backseat on the way to school with an iPhone and watch six Japanese businessmen coming on the face of a girl who has a squid up her vagina—I mean, Jesus! These kids must be so jaded. We should be afraid. What does it do to relationships, how you relate to a girl? That doesn’t mean I wouldn’t have watched that stuff if it was around when I was a kid.”

On radical Islam:

“My reaction once again was that if there are this many bad apples, there’s something wrong with the orchard. The fact remains that Islam is a uniquely intolerant and violent religion at this point in our history. The vast, vast, vast majority of Muslims are not terrorists. But here’s the point people don’t bring up: They’re not terrorists, but they share some very bad ideas with terrorists, and bad ideas lead to bad behavior.”

“At this point we probably need to take out a few bad people. But the long-term solution to radical Islam is to let them have the civil war they need to have between themselves. Let the people who want to walk into the 21st century stand up against the people who want to stay in the seventh century. They need to take out their own trash.”