Some people confuse "publishing tools" with "authoring tools" and this has lead many web publishing shops (and tool vendors while we're at it!) down a blind alley.Not to disparage everyone's favorite authoring applications but when NetObjects' NetFusion or Microsoft's FrontPage works well for someone setting up a web site with 50-100 pages, they may be lulled into believing that they can scale usage of these tools to deal with the constant addition, updating and other maintainence tasks of a web publishing operation.
You probably wouldn't be here if this were working for you, getting a design implemented and an initial setup running is trivial compared to the task of daily maintainence of a web site. Don't let this point get lost next time a web launch specification is being drawn up!
That said, an additional requirement for any publishing system is allowance for editing environments that users like and find familiar. Producers like to develop in Allaire's HomeSite and Macromedia's DreamWeaver, editors seem to prefer Microsoft Word. This can be a vexing problem.