Friends (8 p.m., NBC) begins its new season where it left off, at Monica and Chandler's wedding, where Rachel has some explaining to do. Rose McGowan joins the cast of Charmed (8 p.m., WB), which has a two-hour season opener. She plays Phoebe and Piper's long-lost half-sister Paige, who fills the witching void left by Shannen Doherty's exit. The new sitcom Inside Schwartz (8:30 p.m., NBC) debuts. A guy named Schwartz imagines sports personalities commenting on his sex life. Yes, NBC keeps its 8:30 Thursday loser streak alive! On the season premiere of Will & Grace (9 p.m., NBC), Nathan (Woody Harrelson) and Will vie for Grace time. CSI (9 p.m., CBS) opens season No. 2 with Grissom and Catherine probing the suspicious death of a casino executive. Finch gets fired and takes up with Snoop Dogg on the season premiere of Just Shoot Me (9:30 p.m., NBC). The eighth season opener of ER (10 p.m., NBC) is set over a single day, as Benton has his hands full with family crises, Carter faces his emotionally shuttered parents and Greene hides his role in the death of the day-care shooter.
Astros at Cubs (8 p.m., Fox Family)
Rosie O'Donnell (syndicated) Ana Gasteyer, Jeremy Piven
David Letterman (CBS) Sen. Hillary Rodham Clinton, Don Zimmer
Jay Leno (NBC) Cuba Gooding Jr., Live
Politically Incorrect (ABC) John Waters, Paul Rodriguez
Conan O'Brien (NBC) Kelsey Grammer, Robert Earl Keen
Craig Kilborn (CBS) Natasha Gregson Wagner
All times Eastern unless noted.