This, of course, assumes that nothing unexpected happens to block the nomination, and that Clinton herself wants the job. But the Associated Press' Nedra Pickler writes:
Transition aides said the two camps have worked out financial disclosure issues involving Clinton's husband, former President Bill Clinton, and the complicated international funding of his foundation that operates in more than 40 countries. The aides said Obama and Hillary Clinton have had substantive conversations about the secretary of state job.
Clinton has been mulling the post for several days, but the comments from the transition aides suggested that Obama's team does not feel she is inclined to turn it down.
Similarly, Politico's Mike Allen says two unnamed "senior Obama aides" told him "they expect her to accept."
Separately, the New York Times reports that "Democratic leaders in the Senate are prepared to give Senator Hillary Rodham Clinton a still-undefined leadership role there if she does not become Barack Obama’s secretary of state... The discussions about an enhanced position for Mrs. Clinton are factoring into her deliberations over joining the cabinet."