Intelligence officials say American missiles have killed seven people in a militant stronghold near the Afghan border.
Monday's attack struck the Datta Khel region of North Waziristan.
The officials provided no further details of the strike, and did not give their names because their agency does not allow them to.
The United States has stepped up missile attacks on al-Qaida and Taliban targets inside northwest Pakistan over the last two months. There have been 17 strikes this month, according to an Associated Press count.
Washington does not acknowledge the attacks or say who it is targeting or killing.
Critics say innocents are often killed in the attacks, hurting Pakistan's efforts to win over tribesmen in its campaign against militants.