Stem cells

The know-nothings

Pro-business Republicans and the religious right have joined in a frighteningly successful campaign to undermine the findings of science.

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The know-nothings

It took almost no time for the devastation of New Orleans, in the wake of Hurricane Katrina, to become the newest beachhead in the science wars. On the evening of Sept. 1, when the waters were still rising and we had no idea how much worse things were still going to get, Brit Hume devoted an extended segment of his Fox News program to interviewing Patrick J. Michaels, an environmental scientist at the University of Virginia.

Michaels’ purpose, and Hume’s, was to rebut a widely circulated Op-Ed article by Ross Gelbspan in the Boston Globe arguing that Katrina, and a host of other natural disasters, had been caused or exacerbated by the effects of global warming. A likable, slightly acerbic fellow who refers to himself as a “weather nerd,” Michaels told the Fox audience in judicious, neutral-sounding language that there isn’t much correlation between global warming and hurricane strength — and added, almost as an afterthought, that there isn’t much we can do about global warming anyway.

I don’t know whether Chris Mooney, author of the profoundly discouraging new book “The Republican War on Science,” watched Hume’s broadcast. Probably not — Mooney grew up in New Orleans, and one imagines he had other priorities that night. But if he saw it, or heard about it later, he could only have rolled his eyes, not in surprise but in exasperation: Here we go again. In fairness, Hume told his audience that Michaels is a fellow at the Cato Institute, a libertarian think tank. But he didn’t tell them that Michaels’ work at Cato has been extensively funded by oil and gas companies, or that he’s also affiliated with the George C. Marshall Institute, an industry-supported, right-wing think tank almost exclusively devoted to debunking global warming concerns. Nor did he mention that Michaels edits World Climate Report, a newsletter (and now a blog) primarily funded by the coal industry.

Even more to the point, Hume didn’t reveal that Gelbspan and Michaels are longtime adversaries in the so-called global warming debate; their feud goes back at least 10 years, to a Harper’s article in which Gelbspan outed Michaels as one of the energy industry’s favorite mouthpieces. There are legitimate criticisms one could raise about Gelbspan’s melodramatic Globe Op-Ed: Nobody can say, with any degree of scientific certainty, that global warming caused Katrina (or the other natural disasters he references). But in general terms, Gelbspan’s position reflects the consensus view of climate scientists all over the world that human activity is gradually raising global temperatures and that the consequences may be catastrophic. Michaels, on the other hand, is an exceedingly well-compensated scientific contrarian, a key player in one of the right wing’s biggest industries: the manufacture of doubt.

“The Republican War on Science” is nothing short of a landmark in contemporary political reporting. Mooney compiles and presents an extraordinary mountain of evidence, from several different fields, to demonstrate that the conservative wing of the Republican Party has launched an unprecedented and highly successful campaign to sow widespread confusion about the conclusions of science and its usefulness in political decision making. Using methods and strategies pioneered under the Reagan administration by the tobacco industry and anti-environmental forces, an alliance of social conservatives and corporate advocates has paralyzed or obfuscated public discussion of science on a whole range of issues. Not just climate change but also stem cell research, evolutionary biology, endangered-species protection, diet and obesity, abortion and contraception, and the effects of environmental toxins have all become arenas of systematic and deliberate bewilderment.

Mooney quotes an internal strategy document from the tobacco company Brown and Williamson, written around 1969: “Doubt is our product, since it is the best means of competing with the ‘body of fact’ that exists in the mind of the general public. It is also the means of establishing a controversy.” B&W and the other tobacco giants achieved no better than a stalemate in their long battle against government regulation, but whatever chain-smoking, skinny-tied executive wrote that memo ought to be beatified by the conservative movement. With those two sentences he became its accidental Karl Marx, launching an antiscientific counterrevolution that rages around us today.

No matter how much you think you know about Republican distortion and misuse of science, Mooney’s account will startle and perhaps terrify you. Many conservatives, he argues, have stopped regarding science as an objective search for truth (conditional as that truth necessarily is). Instead, they see it as just another realm of naked power politics or, less cynically but more ominously, as a contest between a pseudo-socialistic, tree-hugging worldview and one that is avowedly pro-Christian and pro-capitalist. Furthermore, right-wingers have mystified this conflict almost completely, cloaking it in self-defined terms of “sound science” (i.e., science that agrees with them, or reaches no conclusions at all) versus “junk science” (anything that might impinge on corporate profits or conflict with the most extreme version of Christian morality).

In several respects this book is a companion piece to Thomas Frank’s highly influential “What’s the Matter With Kansas?” Arguably, it answers one of Frank’s conundrums by providing the philosophical glue that sticks together the two halves of the GOP’s unlikely post-1980 coalition. Affluent big-business conservatives and pro-life “moral values” conservatives (mostly middle class or working class) may have opposing economic interests, as Frank would argue. But they share an urgent desire to undermine public confidence in science, if necessary by manufacturing illegitimate doubt or creating, as Mooney puts it, “a semblance of controversy where it doesn’t actually exist.”

As he further explains, this campaign has been buttressed by the numerous conservative think tanks created in the past 30 years, by the relentless spinning of the Sean Hannity-Rush Limbaugh wing of the media and by an increasingly powerful congressional oligarchy of pro-business, anti-science Republicans. As Mooney documents extensively, Capitol Hill’s worst offenders are probably Oklahoma Sen. James Inhofe, a self-anointed climate expert who has declared global warming “the greatest hoax ever perpetrated on the American people,” and Pennsylvania’s pro-creationist Sen. Rick Santorum.

Perhaps most effectively of all, the right’s war on science has exploited the mainstream media’s fetish for journalistic “balance,” regardless of its relevance to reality. Despite the overwhelming consensus of mainstream science on global warming, newspaper articles and TV reports still dutifully call upon the shrinking universe of contrarians like Michaels. (Like most climate change skeptics, Michaels has slowly retreated, along with the polar icecaps. He used to claim that global warming either wasn’t happening or wasn’t caused by human activity; now he admits to both, but argues that it can’t be stopped and that its potential effects have been exaggerated.)

Similarly, the media has passed along reports emanating from the right-wing fringe suggesting a link between abortion and breast cancer, although virtually no mainstream scientists see any evidence to support such a connection. News accounts about the herbicide atrazine, which is widely used by American corn growers and may be connected to the worldwide decline of frogs and other amphibians, have suggested that the issue is muddled and controversial. If that’s true, it’s only because the chemical industry and its supporters have made it so: Research suggesting that atrazine interferes with the endocrine systems of amphibians has been published in major peer-reviewed scientific journals, while virtually all the conflicting studies have been funded by Syngenta, the company that manufactures atrazine.

If global warming remains the pro-business conservatives’ primary front in the science wars, religious conservatives are more interested in two other issues that have received wide attention: embryonic stem cell research and the teaching of evolution. As throughout “The Republican War on Science,” Mooney’s reporting on these issues is exemplary and his writing admirably clear. But there isn’t much surprising new information here; if you’ve followed these issues, you already know that the Bush administration and its allies have managed to alienate nearly the entire scientific establishment. On one hand, there is the substance of the policies: Bush has sharply restricted federally funded stem cell research and has endorsed the teaching of the pseudo-creationist position called “intelligent design.”

Beyond that, the administration has tried to mislead the public about the nature of its decisions, pretending to embrace science while adopting extreme antiscientific positions. George W. Bush’s August 2001 announcement that he would freeze the number of stem cell lines eligible for federal research included the claim that there were more than 60 “genetically diverse” lines available. That made the decision seem scientifically palatable, but the number wasn’t real then and is less so now. (Again, this is something the mainstream media took months to figure out.) Mooney estimates that 22 stem cell lines qualify for federal funding, and of those only seven or eight may be scientifically useful. Simply put, none of the potential benefits of stem cell research — therapies for Parkinson’s and Alzheimer’s, transplantable tissues, cutting-edge disease research — is likely to be realized by drawing on such a small pool of genetic lines.

Bush’s recent comment that intelligent design should be taught in schools, alongside or in addition to Charles Darwin’s theory of evolution, came after Mooney had finished his manuscript. Again, he can’t have been surprised, since virtually the entire Christian right, a key element of Bush’s governing coalition, has lined up behind intelligent design: Donald Wildmon’s American Family Association, James Dobson’s Focus on the Family, Phyllis Schlafly’s Eagle Forum, the Concerned Women for America and so on. For political leaders like Bush and Santorum, that hasn’t quite been enough. They have relied on the idea that genuine scientific disagreement exists over the validity of evolutionary theory, and that schools need to “teach the controversy,” as intelligent-design supporters put it.

As was recently reported in a New York Times series on the battle over evolution, intelligent design has been vigorously supported by the Discovery Institute, a formerly moderate think tank that has now become the intellectual home of antievolutionism. In 2001, Discovery took out a newspaper ad signed by roughly 70 scientists, who declared that they were “skeptical of the claims for the ability of random mutation and natural selection to account for the complexity of life” — in other words, they rejected Darwinism.

This list has become Exhibit A in the argument that genuine scientific controversy exists over evolution, and to the layperson it certainly looked impressive. Bush and Santorum are not likely, however, to mention the National Center for Science Education’s hilarious response. The NCSE began gathering names of scientists who agreed that evolution was “a vital, well-supported, unifying principle of the biological sciences” — but restricted membership to those whose names were Steve, Stephanie or some other variation of Stephen. As of Monday, “Project Steve” — named in honor of the late Stephen Jay Gould — had 600 signatories.

But while scientists, political junkies and lay readers alike have been understandably mesmerized by these moral-cum-theological crusades, the corporate right has embarked on an immense stealth campaign to undermine science as a regulatory tool. The details of this clandestine effort, conducted mainly in Washington backrooms and the fine print of obscure legislation, are not sexy or glamorous, but it’s here that Mooney’s reporting reaches its most impressive heights. As he demonstrates, a little-known lobbyist named Jim J. Tozzi — a former jazz musician turned corporate hired gun — got “two sentences of legalese” stuck into a 2000 appropriations bill, and thereby handed big business one of its largest legislative victories in history.

Tozzi’s bill, known as the Data Quality Act, has done what Newt Gingrich’s 1994 “Republican Revolution” was unable to do: It has reformed the regulatory process such that big money almost always has the upper hand. As Mooney puts it, the Bush administration has interpreted the act as “an unprecedented and cumbersome process by which government agencies must field complaints over the data, studies and reports they release to the public. It is a science abuser’s dream come true.” Essentially, business interests are now empowered not merely to challenge government regulations (they could already do that) but to challenge the value of “scientific information that could potentially lead to regulation somewhere down the road.”

Any time a scientific study emerges that industry doesn’t like — on the effects of secondhand smoke, the link between atrazine and frog deaths, the near extinction of an endangered fish in a dammed river — lawyers and lobbyists can now tie the science in knots for years to come, requesting reviews and re-reviews and even challenging the findings in court. Aided by friends like Fox News online columnist Steven Milloy — who seems to view all claims of dangerous pollution or species endangerment as “junk science” — corporate advocates can effectively swamp any potential regulation in a mixture of public confusion and “paralysis by analysis.”

Mooney’s litany of conservative assaults on science goes well beyond a listing of interlinked but essentially ad hoc right-wing positions. Rather, this is a well-coordinated campaign, perhaps most noteworthy for the canny and cynical way it manipulates contemporary public doubt about the meaning and value of science. As Thomas Murray, president of the Hastings Center, a bioethics think tank, puts it, “What’s intriguing about the Bush administration, given their views on most issues, is that they have a postmodern take on science. It’s the first postmodern science administration we’ve ever known.”

While Mooney explores this question with his customary clarity and reasonableness, he doesn’t do quite as much with it as he could. Whether knowingly or not, the Bush administration and its allies have cashed in on the findings of the contemporary academic field known as science and technology studies (also as the history and/or philosophy of science). Following such philosophers as Ludwig Wittgenstein, Michel Foucault and Paul Feyerabend, this field has explored science as a cultural phenomenon, arguing (for instance) that even when scientists deal with near-certain facts, the understanding of scientific knowledge and the social uses to which it is put are always culturally specific.

It’s impossible to say how much this arcane field of inquiry has crept into the public consciousness, but let’s put it this way: Ordinary people clearly don’t trust science the way they used to. Mooney, like Frank, points to Barry Goldwater’s 1964 presidential campaign, with its contempt for the “pinhead intellectuals” of the Eastern establishment, as the moment when this meme was established in right-wing ideology. At the time, moderate Republicans ridiculed this tendency, worried that it would doom their party to know-nothing irrelevance; little did they know how dominant it would become.

One could argue, however, that the real roots of science’s contemporary dilemma run much deeper. Conservative contempt for the intellectual and scientific elite is closely akin to the left-leaning, postmodernist spirit of science and technology studies; both reflect the realization that science is a human endeavor and as such prone to errors, blind spots and both ideological and economic manipulation. With Hiroshima, the Holocaust and Chernobyl in the rear-view mirror, the planet poisoned by toxic chemicals and a new frontier of cloning and genetic engineering lying just ahead, it’s reasonable to view the scientific project in toto as a morally cloudy exercise.

Furthermore, doubt is an essential element of scientific inquiry, as any honest scientist will tell you. The great strength of the scientific method lies in its production of testable and falsifiable hypotheses, but it yields absolute truth only gradually, if at all. If our certainty about such things as heliocentrism and the basic laws of earthbound physics now approaches 100 percent, it’s only because they have survived decades or centuries of ruthless inquiry and no better explanations have emerged.

Mooney is especially sensible in discussing the questions that arise here. It is legitimate and even necessary for scientists to challenge the consensus views held by their colleagues. Searching for flaws in widely accepted theories and flying in the face of contemporary wisdom are crucial elements in scientific progress. The germ theory of disease and the idea of continental drift (known today as plate tectonics) were viewed as looney-tunes notions when first proposed; now they are understood as among the very greatest scientific discoveries. We can’t know right now which current scientific belief will look stupid in the 22nd century, but we can be pretty sure something will.

So isn’t it legitimate for Michaels and the other global warming skeptics to poke holes in the dominant scientific paradigm? Of course it is. Fewer and fewer scientists believe they’re right, which doesn’t say much for their probability of success — but Michaels has his own interpretation of the existing data and there’s no reason to doubt his intellectual honesty. What isn’t legitimate is for politicians like Inhofe to stage pseudo-scientific show trials, pitting one lonely contrarian against the overwhelming weight of scientific opinion, and then use the scintilla of doubt thereby created as a reason to do nothing about global warming.

In the words of Rep. George Brown, a California Democrat who has been a leading science watchdog on Capitol Hill, congressional Republicans with little or no scientific background seem to have convinced themselves that “scientific truth is more likely to be found at the fringes of science than at the center.” This is an ideological or perhaps a theological view, but if science is to have any validity in the formation of public policy, then political leaders must understand and respect the scientific consensus.

As historian of science Naomi Oreskes tells Mooney, “Scientific knowledge is the intellectual and social consensus of affiliated experts based on the weight of available empirical evidence, and evaluated according to accepted methodologies.” As noted above, scientists have the freedom and indeed the responsibility to challenge that consensus; with rare exceptions, politicians and the rest of us lack the vocabulary or authority to do so. (Inhofe’s self-administered curriculum in climate science appears to have comprised only authors he already knew he agreed with.)

That’s not the same thing as saying that politicians are bound to make their decisions according to scientific consensus, another point that Mooney makes clear. All we can require from political leaders is honesty. If President Bush had simply said he believed stem cell research was immoral, or Inhofe had said that the economic costs of responding to global warming were too high, those would be legitimate pillars on which to stand. (And others of course would be free to disagree.) In fact, as Mooney notes, the Clinton administration admitted that epidemiological research suggested that needle exchange programs would slow the spread of HIV, but rejected them anyway.

But while science may in some ways have fallen into disrepute, we still live in a scientific and technological age. Conservatives and liberals fly on the same aircraft and rely on the same medical advances to save the lives of their loved ones. So the right has found it necessary to cloak its decisions in ever murkier versions of science, where a more honest conservative ideology might frame them as moral or economic imperatives.

As Mooney puts it, the Bush-era right has pushed the politicization of science to the point of crisis, and not just political crisis. It’s really more like an epistemological crisis; consider the legendary anecdote from Ron Suskind’s October 2004 New York Times Magazine article, in which an unnamed administration official referred mockingly to “the reality-based community.” Suskind writes: “I nodded and murmured something about enlightenment principles and empiricism. He cut me off. ‘That’s not the way the world really works anymore,’ he continued. ‘We’re an empire now, and when we act, we create our own reality.’”

Mooney offers an epilogue in which he suggests that a political alliance of Democrats, independents and moderate Republicans horrified by their own party’s “systematic willingness to misrepresent or even concoct its own ‘science’” can reverse the current trend. But within his pages you won’t find much reason for optimism. By turning science into an endlessly fudgeable tool of politics, and rejecting any notion of scientific consensus in favor of a landscape where all science is either liberal (“junk”) or conservative (“sound”), the American right has fulfilled the darkest prognoses of postmodern philosophy. In this view, science is indeed just an artifact of culture; it has no more objectivity than astrology or dowsing or medieval Catholic theology.

From the point of view of intellectual history, this is a fascinating turn of events. Unhappily, it also has practical consequences. Harvard physicist Lewis Branscomb has written that science as an element of democratic governance, formerly “a strong source of unity in the electorate,” has been fatally eroded. “Policymaking by ideology requires that reality be set aside,” he goes on; “it can be maintained only by moving towards ever more authoritarian forms of government.”

More concretely, and far more eerily, Mooney writes in his introduction that the Bush administration’s refusal to consider mainstream scientific opinion on global warming “could cost our children dearly.” He continues: “That includes children not just in low-lying New Orleans, where I myself grew up, but in low-lying Bangladesh and other nations across the globe.” One imagines that the awful irony of this sentence pains Mooney more every day: At least Bangladeshi children have a government that still belongs to the reality-based community.

Gov. Rick Perry underwent stem cell therapy

...the kind that Christian conservatives like

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Gov. Rick Perry underwent stem cell therapyFILE - In this June 18, 2011 file photo, Texas Gov. Rick Perry speaks at the Republican Leadership Conference in New Orleans. Should Perry conclude that voter discontent has left him an opening to enter the presidential race, the longtime Texas governor would be among the GOP field's most conservative candidates. (AP Photo/Patrick Semansky, File)(Credit: AP)

Rick Perry, the Texas governor who may soon enter the GOP presidential race, is an outspoken critic of stem cell research. Earlier this year he claimed that under the Obama administration, stem cell research was “turning the remains of unborn children into nothing more than raw material.”

It is perhaps surprising to learn, then, that Perry himself was injected with stem cells last month to treat a recurring back injury, as the Texas Tribune revealed. However, Perry was treated with adult stem cells from his own tissue, not embryonic stem cells.

The Texas Tribune points out that Perry’s procedure was nonetheless experimental and controversial: it isn’t FDA approved, has mixed evidence of success and can cost tens of thousands of dollars (and is not covered by insurance). Researchers have also said that “despite the great potential adult stem cells may have, so far they’ve seen nothing more definitive than the so-called ‘placebo effect’.”

On Wednesday, a spokesperson for Perry said that the governor’s “innovative” procedure had been “successful” and The Tribune notes that Perry’s Emerging Technology Fund has already pledged millions of dollars to adult stem cell research.

Although still experimental, adult stem cell therapy is not embroiled in the political quagmire that surrounds embryonic research — a hot button issue for pro-life advocates. That is not to say that Perry’s public endorsement of adult stem cell research won’t have political fallout or consequences for the scientific community.

An article in the Christian Post Thursday is illustrative of this. It notes that according to pro-life advocates, “embryonic stem cell research, besides being immoral, is unnecessary due to the advances in adult stem cell research.”

Conservative Christian groups argue that advancements in adult stem cell research render the use of embryos unnecessary, but scientists are generally skeptical about the effectiveness of adult stem cell injections and still see the use of embryos as crucial to the to the advancement of stem cell research. As Dr. David Baltimore, president of CalTech, told ABC News in April: embryonic stem cell research “[is] one of the most exciting things that has happened in science and we are not allowed to study it.”

Perry’s adult stem cell success story will no doubt serve as a useful weapon in the highly politicized fight against such research.

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Natasha Lennard covers the Occupy movement for Salon. A British-born, Brooklyn-based journalist, she has been covering Occupy Wall Street since before the first sleeping bag was unrolled in Zuccotti Park. One of the first journalists arrested at an Occupy action, she has managed to enrage Andrew Breitbart, Rush Limbaugh and Glenn Beck. You can follow her on Twitter (@natashalennard), and email her any Occupy updates/videos/ideas to natasha.lennard@gmail.com

Justice Department will appeal ruling in stem cell case

Federal judge has blocked additional taxpayer money from being used in embryonic research

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The Obama administration will appeal a court ruling that undercut its efforts to expand stem cell research, the Justice Department said Tuesday.

The appeal is expected this week, said spokesman Matthew Miller.

On Monday, a federal judge ruled that the stem cell research violated the will of Congress in prohibiting the destruction of human embryos.

National Institutes of Health Director Francis Collins said dozens of studies of promising stem cell therapies — about $54 million worth — would have to stop because of the court ruling that temporarily forbids any additional money from being granted.

Monday’s ruling will “drive the best scientific minds into work less likely to yield treatments,” added Sean Tipton of the American Society for Reproductive Medicine. “It will be incredibly disruptive.”

Stem cells reverse blindness caused by burns

In a study deemed a "roaring success," dozens of people regain their vision after transplants

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Dozens of people who were blinded or otherwise suffered severe eye damage when they were splashed with caustic chemicals had their sight restored with transplants of their own stem cells — a stunning success for the burgeoning cell-therapy field, Italian researchers reported Wednesday.

The treatment worked completely in 82 of 107 eyes and partially in 14 others, with benefits lasting up to a decade so far. One man whose eyes were severely damaged more than 60 years ago now has near-normal vision.

“This is a roaring success,” said ophthalmologist Dr. Ivan Schwab of the University of California, Davis, who had no role in the study — the longest and largest of its kind.

Stem cell transplants offer hope to the thousands of people worldwide every year who suffer chemical burns on their corneas from heavy-duty cleansers or other substances at work or at home.

The approach would not help people with damage to the optic nerve or macular degeneration, which involves the retina. Nor would it work in people who are completely blind in both eyes, because doctors need at least some healthy tissue that they can transplant.

In the study, published online by the New England Journal of Medicine, researchers took a small number of stem cells from a patient’s healthy eye, multiplied them in the lab and placed them into the burned eye, where they were able to grow new corneal tissue to replace what had been damaged. Since the stem cells are from their own bodies, the patients do not need to take anti-rejection drugs.

Adult stem cells have been used for decades to cure blood cancers such as leukemia and diseases like sickle cell anemia. But fixing a problem like damaged eyes is a relatively new use. Researchers have been studying cell therapy for a host of other diseases, including diabetes and heart failure, with limited success.

Adult stem cells, which are found around the body, are different from embryonic stem cells, which come from human embryos and have stirred ethical concerns because removing the cells requires destroying the embryos.

Currently, people with eye burns can get an artificial cornea, a procedure that carries such complications as infection and glaucoma, or they can receive a transplant using stem cells from a cadaver, but that requires taking drugs to prevent rejection.

The Italian study involved 106 patients treated between 1998 and 2007. Most had extensive damage in one eye, and some had such limited vision that they could only sense light, count fingers or perceive hand motions. Many had been blind for years and had had unsuccessful operations to restore their vision.

The cells were taken from the limbus, the rim around the cornea, the clear window that covers the colored part of the eye. In a normal eye, stem cells in the limbus are like factories, churning out new cells to replace dead corneal cells. When an injury kills off the stem cells, scar tissue forms over the cornea, clouding vision and causing blindness.

In the Italian study, the doctors removed scar tissue over the cornea and glued the laboratory-grown stem cells over the injured eye. In cases where both eyes were damaged by burns, cells were taken from an unaffected part of the limbus.

Researchers followed the patients for an average of three years and some as long as a decade. More than three-quarters regained sight after the transplant. An additional 13 percent were considered a partial success. Though their vision improved, they still had some cloudiness in the cornea.

Patients with superficial damage were able to see within one to two months. Those with more extensive injuries took several months longer.

“They were incredibly happy. Some said it was a miracle,” said one of the study leaders, Graziella Pellegrini of the University of Modena’s Center for Regenerative Medicine in Italy. “It was not a miracle. It was simply a technique.”

The study was partly funded by the Italian government.

Researchers in the United States have been testing a different way to use self-supplied stem cells, but that work is preliminary.

One of the successful transplants in the Italian study involved a man who had severe damage in both eyes as a result of a chemical burn in 1948. Doctors grafted stem cells from a small section of his left eye to both eyes. His vision is now close to normal.

In 2008, there were 2,850 work-related chemical burns to the eyes in the United States, according to the Bureau of Labor Statistics.

Schwab of UC Davis said stem cell transplants would not help those blinded by burns in both eyes because doctors need stem cells to do the procedure.

“I don’t want to give the false hope that this will answer their prayers,” he said.

Dr. Sophie Deng, a cornea expert at the UCLA’s Jules Stein Eye Institute, said the biggest advantage was that the Italian doctors were able to expand the number of stem cells in the lab. This technique is less invasive than taking a large tissue sample from the eye and lowers the chance of an eye injury.

“The key is whether you can find a good stem cell population and expand it,” she said.

——

Online:

New England Journal: http://www.nejm.org

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How the Super Bowl won me over

I used to be a sports-hating snob. Then I fell for a fan and discovered football is the best reality TV there is

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How the Super Bowl won me over

In 1977, the Oakland Raiders finally made it to the Super Bowl. I was living at the beach that year, temporary roommates with my best friend, Stephen Salinger, a life-long Raiders fan. He made food, invited friends in, cheered through the game and celebrated for days after the Raiders’ decisive 32-14 win against the Minnesota Vikings.

I went surfing.

He couldn’t believe it. I had to be the only man in America not watching the game. It was perverse, it was pathological. It was unpatriotic. But there was a swell running and, in a favorite phrase of mine at the time, football was just “guys jumping into piles” anyway. I thought I was “above” football, but the truth is I was a petty little snob from an Upper East Side, socialist-leaning family. (My mother voted for Adlai Stevenson. Twice.) We went to antiwar demonstrations and Pete Seeger concerts (yes, we sang along), not football games. Running photographs at half-time from Shea Stadium to the pressroom at the Daily News, years before, I had gotten a closer brush with the sport. I came away impressed by the sheer size of the players and the gladiatorial brutality of the game itself. But I wasn’t inspired to watch.

I later became friendly with one of the players on the field that day, Jets cornerback Steve Tannen. We sat in my step-brother’s living room watching another Super Bowl, and he explained what was going on. I still didn’t get it. My smug superior pose was like a suit of armor. I clanked when I walked. An actual NFL player was sitting on a couch with me, explaining the intricacies of the game, and all I could think was, “This is way too complicated for such a dumb sport.”

I might never have discovered the game at all, but around 10 years ago, something completely unexpected happened. I fell in love with a fan.

Annie and I worked together in my contracting business and we were painting a kitchen one Sunday afternoon, when she put on the radio. Not NPR as usual, but an AM station out of New York City, WFAN. The Giants were playing, and she didn’t want to miss the game. She liked listening almost as much as watching, which was convenient since the hated Patriots had knocked the Giants off the Boston television stations most Sundays.

Bob Papa and Dick Lynch called the games better than the boneheads on Fox and ABC, and she liked constructing the plays in her mind from their rapid-fire descriptions: “It’s third and 18, Collins in the shotgun. Amani Toomer split wide left, Cross to the right, Tiki Barber in the slot. Long snap from center. Collins back to pass. He has Amani Toomer up the left side line, he’s all alone … the pass is short, he comes back for the ball, makes the catch, in typical Toomer fashion, dragging both toes in-bounds. That’s a miraculous catch at the 12 yard line and — no, there’s a flag on the play. It’s coming back, folks.”

I didn’t understand most of this. It was like listening to cricket or curling. But Annie sure did. I’ll never forget her howl and rage and frustration at that moment, when it turned out that Roman Oben had forced the holding call.

“What the hell are you doing?!” she shouted at the radio. “They’re killing us with these penalties! You don’t hold there! Not there! Not now! We’re giving them the game! Why can’t they just let them play? Now watch! It’s fourth and inches and Fassel’s going for the field goal! Just give Tiki the ball! Let him run it!” But he didn’t, and the kick went wide. Another dismal day for the Giants.

But the fans were used to days like that, in the lean years before the great squad of the mid-’80s and the tough years since. And at the end of all those seasons, they’d just sigh and say, “Maybe next year…” There was always plenty of time to lick your wounds and prepare for the next season: It was a long way to September.

Eventually I learned the terminology, and more and more every Sunday I got drawn into the games. It had happened the same way for Annie, as a little girl, sitting with her dad, watching the games on television — or traveling to Yankee Stadium, and even the Yale Bowl, during those seasons when the Giants didn’t have a venue of their own. Football turned into the best way to spend time with him: It gave them an endlessly fascinating topic in common, and a perfect strategy for getting to know her otherwise difficult and remote father. A few years later I saw “Remember the Titans,” and thought I glimpsed a little of Annie in the white coach’s 10-year-old daughter, screaming at the TV. Not that much has changed. She still paces and chides and screams, “GO DEFENSE,” on those crucial goal-line stands. I don’t think Annie sat down once through the whole of Super Bowl 44, when the Giants triumphed in their rematch with the hated Patriots.

She’s had her glory moments as a fan. She submitted a song about the team — lyrics to the tune of Ora Lee — in a FAN contest, and won it. She wound up singing on the radio with Offensive Tackle Karl Nelson. Bob Papa had written “Good” on the sheet she submitted — as terse and emphatic as the call on an extra point. Some sample lyrics:

Twelve and Four

Twelve and Four

We are playoff bound

With Stephen Baker in the air

And Otis on the ground

A friend of Annie’s worked for the New Yorker, and the big day got written up as a Talk of the Town piece.

Cool.

The more I watched, the more I fell in love with the game. I gloried in the spectacular pounding the Giants gave the Vikings on the way to that other Super Bowl, in 2000 — and suffered through their humiliating loss to the Ravens, a few weeks later. We drove all the way down to Connecticut for that calamity. Annie’s whole family was morbidly in tune with the team, reading the mood on the field even before the kickoff. “They look flat,” her dad announced as the Giants ran out onto the field. It seemed nuts to me, but they were right. “It’s all about emotion,” Annie told me, and I began to sense that myself, feeling the shifts in psychic energy on the field with that crucial touchdown before the halftime, or the break in concentration when the other team called a disruptive timeout.

With the increasing popularity of so-called reality TV and the cultural ascendance of unscripted drama — from “The Amazing Race” to “American Idol,” from “Survivor” to “The Biggest Loser” — I started to realize a curious small truth: Football is our true reality TV, and our most fascinating unscripted drama. I had seen football movies like “Varsity Blues,” where the final victory was a foregone conclusion. In the actual game, anything can happen. An interception or a turnover, a miscalculated on-side kick, can turn a game upside down.

I realized that football defines itself through series of paradoxes. It represents a kind of utopian view of America, where people work together toward a common goal, a world without rancor or racism, a peaceable kingdom … where men are broken and battered in ferocious combat every week. It’s a brutal sport that rewards elegance and grace, that elevates men to unparalleled stardom through intricate self-effacing military teamwork; a bruising physical competition that relies on levels of knowledge and intuition and cerebral analysis that would give an MIT statistics professor pause. It takes place on a hundred-yard playing field, and yet any individual game can be decided by a matter of inches; it plays itself out over almost four hours but so often resolves itself in the last few seconds — that overtime field goal in the air as the clock runs down.

It draws families together, like Annie’s; and friends, like Stephen and me (we commiserate now, about the Raiders and the Giants); and cities, like New Orleans and Indianapolis, whose teams will be duking it out this Sunday in Miami. And it gives us an extraordinarily diverse cast of characters to enjoy: the old legends thinking about retirement, the kids scoring their first NFL touchdowns ever, in the autumn sunlight; the younger brother struggling in his brother’s shadow and the older brother moving closer to the title of greatest quarterback of all time, and closing in on it this weekend, beyond the glory of another ring. And the other players who’ll never get the ring — Tiki Barber, who retired too soon; or Barry Sanders, quitting because he was contractually bound to play out his career with a losing team. All the great careers ruined by traffic accidents and drug scandals, or by carrying a loaded gun in the waistband of your sweat pants and accidentally shooting yourself in the leg.

It’s a complex, fascinating world and I know I’m a part of it at last as I wait for Peyton to throw that first pass on Sunday, and wonder what happened to his little brother’s team, lying down to be trampled by the Vikings in a humiliating final game, and blow out a long breath and say, “Oh well. Maybe next year.”

I’ll be watching the Combine and the draft on the NFL channel, discussing the prospects with my family. (The Giants need help on their offensive line.) It’s not much, but I’ll take what I can get.

It’s a long way to September. 

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What would Jesus do with a frozen embryo?

It's an interesting question, but let's keep in mind that not everyone's asking it

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After my first reading of a Chicago Tribune article about parents deciding what to do with leftover embryos following IVF treatment, I was so confused I had to consult my smart friend Laura. I IM’ed her the link and asked, “Am I crazy, or does this article totally take it on faith (ha!) that everyone deciding what to do with an embryo is religious?” Laura’s verdict? “Man, those babies in the picture are cute. Especially the yawning one.” Also, “You are definitely not crazy. This is an article about Christians struggling with this decision, which is very interesting, but nowhere in the article does the writer specify that.”

Technically, that’s not true — 11 paragraphs into the article, the religions of the couple in question, Adrianna and Robert Potter, are mentioned (she’s a lapsed Catholic, he’s a Methodist). And after 10 paragraphs, the author, Manya A. Brachear, notes, “Such decisions, doctors say, are often informed and framed by faith” — which is enough to justify focusing on that angle for one article. But it would be nice if said article either led with a clear indication that it was doing just that, or else acknowledged that “What would Jesus do?” is not the central question facing every couple with embryos in storage. Laura continues, “There is no one saying, ‘Hey, guess what, embryos aren’t people’ — whether that comes from a scientist, an atheist, or simply a different set of Christians. There’s also no ‘here are some of the things that stem cell research is used for’ info. It’s all, ‘Your dead babies will go to Science, whatever that is.’”

That’s an exaggeration, but not by all that much. Writes Brachear, “At this time last year, doctors say, the absence of government funds combined with the economic downturn stalled most meaningful embryonic science, making donations to research a riskier and more radical option. Some laboratories stopped accepting donations, forcing some fertility centers to hold on to embryos despite parents’ preference to devote them to research.” So, wait, deciding that you’d like your embryos to go to science somehow becomes “risky” and “radical” if there’s a chance they might not be used for research? I guess that makes sense if, like Adrianna Potter, you only favor donating embryos to science to promote “the creation of new life” — she notes that research led to their ability to conceive via IVF, and would like to help other couples. Her husband, Robert, either wants to keep them “to fulfill God’s mandate to be fruitful and multiply” or donate them to another infertile couple. So for them, donating embryos to science with no guarantee that they’ll be used might indeed seem risky and/or radical. But what about couples who make that choice simply because they’d rather see the embryos go to good use than discard them? Because they believe in the promise of stem cell research — and at this time last year, were probably hoping that Obama would revoke the ban on federal funding for it, which he did? At this point in the article, there’s still been no clear acknowledgment that this particular debate has a faith-specific context — but any other context is completely ignored.

And that’s the subtle part. Later, Brachear writes, “Robert doesn’t trust that every embryo [donated to science] fulfills a greater purpose. He can’t imagine sentencing two potential children to short lives that would end in a laboratory.” I’m sorry, I can get on board with “potential children,” emphasis on potential, but short lives? No. The idea that an embryo has a “life” that can be ended, even when it’s never seen the inside of a woman’s uterus, is a purely religious one; Robert seems to hold that belief as part of his faith, which is fine, but could we please get some quotation marks, or even a non-specific “he said” on that? Because otherwise, you’re asking the reader to accept the concept of embryonic personhood as a given. And boy, this reader doesn’t.

As Laura said, an article about Christians struggling with a decision that raises serious questions about their own faith versus science is a very interesting idea — and if the headline or subhead or first nine and a half paragraphs indicated that that is, in fact, the subject here, I would have an entirely different take on the execution. Instead, a peculiarly religious dilemma is universalized — “Families struggle with science, faith,” reads the subhead — and people who have no faith-based qualms about donating embryos to science (including many religious people, as well as those who don’t have faith-basied qualms, period) are simply not acknowledged. Not to mention, “struggling with science” is presented as wondering whether your embryos’ “lives” will have meaning in a lab — which, call me crazy, still sounds more like struggling with faith. At a time when anti-choice groups are sincerely attempting to redefine personhood as “the beginning of biological development” — raising the possibility of everything from miscarriages being investigated as potential homicides to pregnant women qualifying for the carpool lane — blurring the line between religious beliefs and observable facts is what I would call “risky” and “radical.” 

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Kate Harding is the co-author of "Lessons From the Fatosphere: Quit Dieting and Declare a Truce With Your Body" and has been a regular contributor to Salon's Broadsheet.

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