UPDATE: John Miksad, Con Ed's Sr. V.P. of Electic Operations, has confirmed to NY1 that the explosion occurred at one of the company's substations, knocking out power for 230,000 to 250,000 residents in parts of Lower Manhattan and Brooklyn. There were no reported injuries.
DNAinfo has posted video of what they're calling an explosion at the Con Ed power plant on E. 14 St. and FDR Dr. The action begins at the 20-second mark.